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The roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens

The effects of three selective oral inhibitors, fluvoxamine (FLU), ketoconazole (KET), and verapamil (VER), on the pharmacokinetics (PK) of florfenicol (FFC) were investigated in chickens. The chickens were administered orally with saline solution (SAL), FLU (60 mg/kg), KET (25 mg/kg), or VER (9 mg/kg) for 7 consecutive days. Florfenicol was given to the chickens at a single dose of 30 mg/kg or...

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Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.

Cytochrome P450 (P450) 2S1 is one of the orphan P450s without a clear physiological function. Controversy has arisen as to whether it can interact with NADPH-P450 reductase and accept electrons. The reduction of 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione (AQ4N) by P450 2S1 was confirmed, and the NADPH consumption rates were measured aerobically and anaerob...

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Cytochrome p450 Genotyping

©2017 Blue Cross and Blue Shield of Louisiana An independent licensee of the Blue Cross and Blue Shield Association No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, or otherwise, without permission from Blue Cross and Blue Shield of Louisiana. Page 1 of 28 Applies to all products admin...

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Cytochrome p450 Genotyping

©2017 Blue Cross and Blue Shield of Louisiana An independent licensee of the Blue Cross and Blue Shield Association No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, or otherwise, without permission from Blue Cross and Blue Shield of Louisiana. Page 1 of 28 Applies to all products admin...

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Zolpidem and cytochrome P450

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse. These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4).. .. Covera HS, Isoptin SR, Verelan); Warfarin (coumadin); Zolpidem (Ambien): Little or no interaction with grapefruit juice. The aim of this study was to identify the form(s) of cytochrome P450 (CYP) responsibl...

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ژورنال

عنوان ژورنال: Human Genomics

سال: 2009

ISSN: 1479-7364

DOI: 10.1186/1479-7364-4-1-59